Professors Julio Bacarizo and Ana Cámara-Artigas, from the University of Almería, have resolved at atomic resolution crystal structures of the Thr98Asp c-Src SH3 domains mutant in complex with the high affinity peptide APP12. These protein structures are the first solved at atomic resolution in Alba. Information obtained at XALOC beamline could have implications in pathologies such as cancer, AIDS or osteoporosis.
The structures obtained at BL13-XALOC correspond to the complexes of LC8 homodimers (yellow and orange) with the phosphorylated (right, PDB ID 3ZKF) and non-phosphorylated (left PDB ID 3ZKE) versions of a Nek9 peptide.
