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Synchrotron XRPD for the enhanced characterization of pharmaceuticals

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Dr. Fabia Gozzo. Excelsus Structural Solutions SPRL, Belgium & Excelsus Structural Solutions (Swiss) AG, Switzerland
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events
When
Mar 20, 2015 from 09:30 AM to 10:30 AM (Europe/Madrid / UTC100)
Where
ALBA Marie Curie meeting room
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X-Ray Powder Diffraction (XRPD) is considered as the gold standard method in the field of pharmaceutical powders for the identification of solid forms (i.e. polymorphs, solvates, hydrates, salts, co-crystals, amorphous). When combined with a synchrotron X-ray beam, XRPD becomes a very powerful analytical tool, which significantly enhances the characterization of pharmaceuticals.

Advances in instrumentation, calibration and data collection procedures are discussed leading to detection limits of contaminating crystalline phases better than 0.05% wt% as well as the disclosure of subtle structural details. SR-XRPD technique and instrumentation applied to the study of pharmaceuticals is discussed together with relevant examples of applications.

We also discuss the experience of Excelsus Structural Solutions in bringing these techniques and analyses successfully at the service of pharmaceutical and chemical companies. The modalities of the fast, easy and affordable access to these state-of-the-art analytical tools are also discussed.

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